Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 17/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 15/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 14/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | PRKX | P51817 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448446 | 0.95 | SIRT2 (0.47) | SIRT2SIRT3SIRT1AKT1DYRK3 | |
| SCHEMBL9448322 | 0.87 | SIRT2 (0.48) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448549 | 0.87 | SIRT2 (0.48) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448404 | 0.85 | SIRT2 (0.49) | SIRT2SIRT3SIRT1MKNK2 | |
| SCHEMBL8262940 | 0.82 | SIRT2 (0.47) | SIRT2SIRT3SIRT1AKT1DYRK3 | |
| SCHEMBL5036891 | 0.81 | PLA2G2A (0.46) | — | |
| SCHEMBL9448330 | 0.81 | SIRT2 (0.46) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448400 | 0.80 | SIRT2 (0.50) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448534 | 0.80 | PARP10 (0.56) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9952887 | 0.80 | SIRT2 (0.50) | SIRT2SIRT3SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5215738-A | Used for destroying hypoxic tumor cells | SRI INTERNATIONAL (US) | 1993-06-01 | — | — | US | disclosed |
| WO-1986006628-A1 | BENZAMIDE AND NICOTINAMIDE RADIOSENSITIZERS | SRI INTERNATIONAL (US) | 1986-11-20 | — | — | WO | disclosed |