Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | F3 | P13726 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | SI | P14410 | 1/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448690 | 1.00 | MAPT (0.65) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL9006623 | 0.84 | MAPT (0.48) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL9006627 | 0.84 | MAPT (0.48) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL15436912 | 0.84 | MAPT (0.67) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL10977635 | 0.82 | MAPT (0.65) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL21028263 | 0.82 | MAPT (0.65) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL17899528 | 0.82 | MAPT (0.65) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL10977632 | 0.82 | MAPT (0.65) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL14012043 | 0.81 | MAPT (0.69) | MAPTNPC1RAB9AMAPK1HTT | |
| SCHEMBL16807421 | 0.81 | MAPT (0.69) | MAPTNPC1RAB9AMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528975-A4 | GROWTH INHIBITORS AND METHODS OF TREATING CANCER AND CELL PROLIFERATIVE DISEASES | — | 1993-09-15 | — | — | EP | claimed |
| EP-0528975-A1 | GROWTH INHIBITORS AND METHODS OF TREATING CANCER AND CELL PROLIFERATIVE DISEASES | BAYLOR COLLEGE OF MEDICINE (US) | 1993-03-03 | — | — | EP | claimed |
| WO-1991017749-A1 | GROWTH INHIBITORS AND METHODS OF TREATING CANCER AND CELL PROLIFERATIVE DISEASES | BAYLOR COLLEGE OF MEDICINE (US) | 1991-11-28 | — | — | WO | claimed |