Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448915 | 0.84 | ALDH1A1 (0.51) | TSHRALDH1A1MEN1KMT2AHTT | |
| SCHEMBL30345150 | 0.84 | ALDH1A1 (0.47) | TSHRALDH1A1MEN1KMT2AHTT | |
| SCHEMBL9449158 | 0.84 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AHTTHIF1A | |
| SCHEMBL3932495 | 0.84 | ALDH1A1 (0.47) | TSHRALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3867227 | 0.83 | TSHR (0.49) | TSHRALDH1A1MEN1KMT2AHTT | |
| SCHEMBL20496758 | 0.80 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AHTTHIF1A | |
| SCHEMBL9448974 | 0.80 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AHTTHIF1A | |
| SCHEMBL9448828 | 0.80 | ALDH1A1 (0.47) | TSHRALDH1A1MEN1KMT2AHTT | |
| SCHEMBL11597017 | 0.79 | CA1 (0.51) | ALDH1A1MEN1KMT2AHTTHIF1A | |
| SCHEMBL2073722 | 0.79 | ALDH1A1 (0.61) | TSHRALDH1A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10093609-B2 | TAK1 kinase inhibitors, compositions, and uses related thereto | EMORY UNIVERSITY (US) | 2018-10-09 | — | — | US | disclosed |
| US-20170369417-A1 | TAK1 Kinase Inhibitors, Compositions, and Uses Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-12-28 | — | — | US | disclosed |
| US-9751825-B2 | TAK1 kinase inhibitors, compositions, and used related thereto | EMORY UNIVERSITY (US) | 2017-09-05 | — | — | US | disclosed |
| US-20140249199-A1 | TAK1 KINASE INHIBITORS, COMPOSITIONS, AND USED RELATED THERETO | HEALTH RESEARCH, INC. (US) | 2014-09-04 | — | — | US | disclosed |
| WO-2013012998-A1 | TAK1 KINASE INHIBITORS, COMPOSITIONS, AND USED RELATED THERETO | EMORY UNIVERSITY (US) | 2013-01-24 | — | — | WO | disclosed |
| EP-0466730-B1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1993-07-21 | — | — | EP | disclosed |
| US-5220021-A | Geminal bisphosphonic acids and derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0466730-A1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS. | UPJOHN CO (US) | 1992-01-22 | — | — | EP | disclosed |
| WO-1990012017-A1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1990-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10093609-B2 | TAK1 kinase inhibitors, compositions, and uses related thereto | TAB1, MAP3K1, MAP3K6 | TSHR 4115/4885ALDH1A1 3504/4885MEN1 1537/4885 |
| US-20140249199-A1 | TAK1 KINASE INHIBITORS, COMPOSITIONS, AND USED RELATED THERETO | TAB1, MAP3K1, MAP3K6 | TSHR 4112/4885ALDH1A1 3574/4885MEN1 1525/4885 |
| US-20170369417-A1 | TAK1 Kinase Inhibitors, Compositions, and Uses Related Thereto | TAB1, MAP3K1, MAP3K6 | TSHR 4115/4885ALDH1A1 3504/4885MEN1 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.