Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 9/20 | 0.72 |
| ▸ | NPC1 | O15118 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487005 | 0.92 | RAB9A (0.77) | HPGDNPSR1RAB9ANPC1MAPT | |
| Hydrochloric Acid SCHEMBL8483511 | 0.91 | RAB9A (0.74) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL8482870 | 0.91 | RAB9A (0.69) | HPGDNPSR1RAB9ANPC1MAPT | |
| Amphotalide SCHEMBL1229739 | 0.89 | RAB9A (0.68) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL31030951 | 0.87 | HPGD (0.79) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL29237869 | 0.87 | HPGD (0.79) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL1578469 | 0.86 | RAB9A (0.83) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL18074274 | 0.85 | HPGD (1.00) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL1677061 | 0.84 | RAB9A (1.00) | HPGDNPSR1RAB9ANPC1MAPT | |
| SCHEMBL8346723 | 0.84 | HPGD (0.74) | HPGDNPSR1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5219863-A | Treating hypertension and congestive heat failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-15 | — | — | US | disclosed |
| EP-0487252-A1 | Quinoline and 1,5-Naphthyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-05-27 | — | — | EP | disclosed |