Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | ICMT | O60725 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187777 | 0.82 | CDC25A (0.59) | CDC25APLK1ALDH1A1LMNAMCL1 | |
| SCHEMBL18180209 | 0.80 | CDC25A (0.63) | CDC25APLK1ALDH1A1LMNAMCL1 | |
| SCHEMBL3743075 | 0.79 | CDC25A (0.70) | CDC25APLK1ALDH1A1LMNAMCL1 | |
| SCHEMBL29379289 | 0.78 | CDC25A (0.68) | CDC25APLK1ALDH1A1LMNAMCL1 | |
| SCHEMBL2465449 | 0.78 | CDC25A (0.68) | CDC25APLK1ALDH1A1LMNAMCL1 | |
| SCHEMBL2051630 | 0.78 | ALDH1A1 (0.80) | CDC25APLK1ALDH1A1LMNA | |
| SCHEMBL28370205 | 0.77 | CDC25A (0.67) | CDC25APLK1ALDH1A1LMNAMCL1 | |
| SCHEMBL29376139 | 0.77 | CDC25A (0.67) | CDC25APLK1ALDH1A1LMNAMCL1 | |
| SCHEMBL15747715 | 0.77 | CDC25A (0.80) | CDC25APLK1ALDH1A1LMNAMCL1 | |
| SCHEMBL28365667 | 0.76 | CDC25A (0.62) | CDC25APLK1ALDH1A1LMNAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229413-A | Nervous system disorders | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5137910-A | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders | C.D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0396124-A2 | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders | G.D. Searle & Co. (US) | 1990-11-07 | — | — | EP | disclosed |