Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29756470 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1FOLH1HTTHSD17B10 | |
| SCHEMBL21808612 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1FOLH1HTTHSD17B10 | |
| SCHEMBL7463580 | 0.87 | KDM4E (0.71) | KDM4EALDH1A1FOLH1HTTHSD17B10 | |
| SCHEMBL3069354 | 0.84 | KDM4E (0.68) | KDM4EALDH1A1FOLH1HTTHSD17B10 | |
| SCHEMBL1093663 | 0.83 | KDM4E (0.67) | KDM4EALDH1A1FOLH1HTTHSD17B10 | |
| SCHEMBL7905354 | 0.83 | EGFR (0.66) | KDM4EALDH1A1FOLH1HTTHSD17B10 | |
| SCHEMBL13701155 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1FOLH1HTTHSD17B10 | |
| SCHEMBL7431193 | 0.83 | ALDH1A1 (0.55) | KDM4EALDH1A1FOLH1HTTHSD17B10 | |
| SCHEMBL5002301 | 0.83 | KDM4E (0.61) | KDM4EALDH1A1FOLH1HTTHSD17B10 | |
| SCHEMBL17683584 | 0.82 | HTR2A (0.56) | KDM4EALDH1A1GAAMAPTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229413-A | Nervous system disorders | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5137910-A | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders | C.D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |