Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.60 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951335 | 1.00 | S1PR1 (0.60) | S1PR1S1PR4S1PR5S1PR3S1PR2 | |
| SCHEMBL948551 | 0.83 | S1PR1 (0.68) | S1PR1S1PR4S1PR5S1PR3S1PR2 | |
| SCHEMBL945959 | 0.83 | S1PR1 (0.68) | S1PR1S1PR4S1PR5S1PR3S1PR2 | |
| SCHEMBL947010 | 0.83 | S1PR1 (0.68) | S1PR1S1PR4S1PR5S1PR3S1PR2 | |
| SCHEMBL945492 | 0.79 | S1PR1 (0.76) | S1PR1S1PR4S1PR5S1PR3S1PR2 | |
| SCHEMBL945493 | 0.79 | S1PR1 (0.76) | S1PR1S1PR4S1PR5S1PR3S1PR2 | |
| SCHEMBL945167 | 0.79 | S1PR1 (0.81) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL945165 | 0.79 | S1PR1 (0.81) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL12943856 | 0.78 | S1PR1 (0.55) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL2562956 | 0.77 | S1PR1 (0.80) | S1PR1S1PR4S1PR5S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | claimed |
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |