Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.81 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.81 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.81 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945165 | 1.00 | S1PR1 (0.81) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL945860 | 0.92 | S1PR1 (0.71) | S1PR1S1PR5S1PR4 | |
| SCHEMBL2565705 | 0.89 | S1PR1 (1.00) | S1PR1S1PR5S1PR4 | |
| SCHEMBL2567881 | 0.89 | S1PR1 (1.00) | S1PR1S1PR5S1PR4 | |
| SCHEMBL2562414 | 0.89 | S1PR1 (1.00) | S1PR1S1PR5S1PR4 | |
| SCHEMBL947010 | 0.89 | S1PR1 (0.68) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL948551 | 0.89 | S1PR1 (0.68) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL945959 | 0.89 | S1PR1 (0.68) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL2559131 | 0.85 | S1PR1 (0.80) | S1PR1S1PR5S1PR4 | |
| SCHEMBL2565470 | 0.84 | S1PR1 (0.78) | S1PR1S1PR5S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | claimed |
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |