Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | HTT | P42858 | 5/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023745 | 0.94 | TDP1 (0.70) | TDP1LMNASMN1; SMN2HTTAPAF1 | |
| SCHEMBL226221 | 0.85 | TDP1 (0.70) | TDP1LMNASMN1; SMN2HTTAPAF1 | |
| SCHEMBL10130604 | 0.84 | TDP1 (0.66) | TDP1LMNASMN1; SMN2HTTAPAF1 | |
| SCHEMBL13723111 | 0.83 | TDP1 (0.64) | TDP1LMNASMN1; SMN2HTTAPAF1 | |
| SCHEMBL6174975 | 0.83 | TDP1 (0.68) | TDP1LMNASMN1; SMN2HTTAPAF1 | |
| SCHEMBL9181106 | 0.82 | TDP1 (0.62) | TDP1LMNASMN1; SMN2HTTAPAF1 | |
| SCHEMBL10894684 | 0.81 | TDP1 (0.66) | TDP1LMNASMN1; SMN2HTTAPAF1 | |
| SCHEMBL2380384 | 0.81 | TDP1 (0.65) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| SCHEMBL230355 | 0.80 | TDP1 (0.63) | TDP1LMNASMN1; SMN2HTTAPAF1 | |
| SCHEMBL229631 | 0.79 | TDP1 (0.61) | TDP1LMNASMN1; SMN2HTTAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0541720-A4 | GOLFOMYCIN DERIVATIVES: NOVEL FUSED RING CYCLODECADIYNE DERIVATIVES | — | 1993-09-01 | — | — | EP | disclosed |
| EP-0541720-A1 | GOLFOMYCIN DERIVATIVES: NOVEL FUSED RING CYCLODECADIYNE DERIVATIVES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992002480-A1 | GOLFOMYCIN DERIVATIVES: NOVEL FUSED RING CYCLODECADIYNE DERIVATIVES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1992-02-20 | — | — | WO | disclosed |