Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9450727 | 0.86 | FOLH1 (0.48) | ALDH1A1KDM4EPOLBPTGER1FOLH1 | |
| SCHEMBL9450848 | 0.84 | FOLH1 (0.46) | ALDH1A1KDM4EPOLBPTGER1FOLH1 | |
| SCHEMBL9450746 | 0.82 | FOLH1 (0.45) | ALDH1A1KDM4ESMN1; SMN2POLBPTGER1 | |
| SCHEMBL6640544 | 0.81 | PTGER1 (0.52) | KDM4EPTGER1FOLH1MCL1MEN1 | |
| SCHEMBL19679231 | 0.77 | FOLH1 (0.56) | ALDH1A1KDM4ESMN1; SMN2POLBPTGER1 | |
| SCHEMBL18497724 | 0.76 | MAPT (0.45) | KDM4ESMN1; SMN2PTGER1MCL1STAT3 | |
| SCHEMBL9450663 | 0.76 | TLR9 (0.46) | KDM4EPTGER1FOLH1ELANEEGFR | |
| SCHEMBL18497755 | 0.76 | CNR1 (0.45) | ALDH1A1KDM4EHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL28421209 | 0.76 | TLR9 (0.49) | HPGDSMN1; SMN2ELANESRD5A1SRD5A2 | |
| SCHEMBL29111072 | 0.76 | ELANE (0.48) | HPGDSMN1; SMN2ELANESRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250691-A | Heteroaryl derivatives of monocyclic beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0531976-A1 | Heteroaryl derivatives of monocyclic beta-lactam antibiotics | E.R. SQUIBB & SONS, INC. (US) | 1993-03-17 | — | — | EP | disclosed |