Glycine

SCHEMBL9450801

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)O)C(C)O.NCC(=O)O

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1 ADORA2A ADORA2B ADORA3 PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D

The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	GLP1R	P43220	17/20	0.72

▸	CCKBR	P32239	1/20	0.71

▸	GCGR	P47871	5/20	0.70

▸	GIPR	P48546	1/20	0.69

▸	NR3C1	P04150	2/20	0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4755	1.00	GLP1R (0.72)	GLP1RCCKBRGCGRGIPRNR3C1
SCHEMBL23721788	1.00	GLP1R (0.72)	GLP1RCCKBRGCGRGIPRNR3C1
Zinc Ion SCHEMBL3043764	0.99	GLP1R (0.72)	GLP1RCCKBRGCGRGIPRNR3C1
Hydrochloric Acid SCHEMBL20883	0.99	GLP1R (0.72)	GLP1RCCKBRGCGRGIPRNR3C1
SCHEMBL6432383	0.99	GLP1R (0.72)	GLP1RCCKBRGCGRGIPRNR3C1
SCHEMBL30721605	0.99	GLP1R (0.73)	GLP1RCCKBRGCGRGIPRNR3C1
Acetic Acid SCHEMBL4351476	0.99	GLP1R (0.71)	GLP1RCCKBRGCGRGIPRNR3C1
Hydrochloric Acid SCHEMBL4743028	0.99	GLP1R (0.71)	GLP1RCCKBRGCGRGIPRNR3C1
Hydrochloric Acid SCHEMBL4743032	0.99	GLP1R (0.71)	GLP1RCCKBRGCGRGIPRNR3C1
SCHEMBL20945961	0.98	GLP1R (0.71)	GLP1RCCKBRGCGRGIPRNR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0546013-A4	GLUCAGON ANALOGS WITH ASP?9 REPLACEMENTS OR DELETIONS	—	1993-09-15	—	—	EP	disclosed
EP-0546013-A1	GLUCAGON ANALOGS WITH ASP-9 REPLACEMENTS OR DELETIONS	THE ROCKEFELLER UNIVERSITY (US)	1993-06-16	—	—	EP	disclosed
WO-1992004042-A1	GLUCAGON ANALOGS WITH ASP9 REPLACEMENTS OR DELETIONS	THE ROCKEFELLER UNIVERSITY (US)	1992-03-19	—	—	WO	disclosed