⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL947265 | 0.88 | — | — | |
| SCHEMBL193923 | 0.82 | — | — | |
| SCHEMBL477201 | 0.78 | — | — | |
| SCHEMBL3505790 | 0.78 | — | — | |
| SCHEMBL946959 | 0.78 | — | — | |
| SCHEMBL1462392 | 0.75 | — | — | |
| SCHEMBL2279540 | 0.75 | — | — | |
| SCHEMBL946962 | 0.75 | KDM4E (0.32) | — | |
| SCHEMBL946809 | 0.75 | — | — | |
| SCHEMBL5504195 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135379-B1 | ANTITUMOR DIBENZOFLUORENE DERIVATIVES | REGENTS BOARD OF (US) | 2004-10-06 | — | — | EP | claimed |
| EP-0675169-B1 | Cationic thiadiazole dyes | BAYER AG (DE) | 1998-09-16 | — | — | EP | claimed |
| EP-0816351-A1 | Functional N-vinylformamides, process for their preparation and their use in free radical polymerisation reactions | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1998-01-07 | — | — | EP | claimed |
| US-5580964-A | USED FOR DYEING AND PRINTING PAPER IN LIGHTFAST SHADES, AS DICHROIC DYES FOR POLARIZING FILMS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-03 | — | — | US | claimed |
| EP-0675169-A2 | Cationic thiadiazole dyes | BAYER AG (DE) | 1995-10-04 | — | — | EP | claimed |
| US-7989446-B2 | 4-amino 5-cyanopyrimidine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-08-02 | — | — | US | disclosed |
| US-20110009620-A1 | 4-Amino-5-cyanopyrimidine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. | 2011-01-13 | — | — | US | disclosed |
| US-7834002-B2 | 4-amino-5-cyanopyrimidine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| US-20080182854-A1 | 4-Amino-5-Cyanopyrimidine Derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-07-31 | — | — | US | disclosed |
| US-7250435-B2 | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-07-31 | — | — | US | disclosed |
| EP-1740574-B1 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2007-06-27 | — | — | EP | disclosed |
| EP-1740574-A2 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | Otsuka Pharmaceutical Company, Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| US-20050261353-A1 | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2005-11-24 | — | — | US | disclosed |
| WO-2005105778-A2 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-11-10 | — | — | WO | disclosed |
| US-6413957-B1 | CYCLIN DEPENDANT KINASES INHIBITORS; CONTROLLING CELL GROWTH AND DIFFERENTIATION; CANCER, PSORIASIS, LEUKOCYTE IMMUNO-LOGICAL DISORDERS, RESTINOSIS AND OTHER SMOOTH MUSCLE CELL DISORDERS | BRISTOL-MYERS SUIBB PHARMA COMPANY | 2002-07-02 | — | — | US | disclosed |
| EP-0675169-B1 | Cationic thiadiazole dyes | BAYER AG (DE) | 1998-09-16 | — | — | EP | disclosed |
| US-5728878-A | USEFUL AS MONOMERS | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1998-03-17 | — | — | US | disclosed |
| EP-0816351-A1 | Functional N-vinylformamides, process for their preparation and their use in free radical polymerisation reactions | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5580964-A | USED FOR DYEING AND PRINTING PAPER IN LIGHTFAST SHADES, AS DICHROIC DYES FOR POLARIZING FILMS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-03 | — | — | US | disclosed |
| EP-0675169-A2 | Cationic thiadiazole dyes | BAYER AG (DE) | 1995-10-04 | — | — | EP | disclosed |