Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10906582 | 0.86 | HTT (0.47) | HTTSMN1; SMN2HPGDTSHROPRM1 | |
| SCHEMBL9456892 | 0.86 | HPGD (0.44) | HTTSMN1; SMN2HPGDTSHRBPTF | |
| SCHEMBL9456736 | 0.85 | SMN1; SMN2 (0.59) | HTTSMN1; SMN2HPGDTSHR | |
| SCHEMBL9456545 | 0.85 | HTT (0.59) | HTTSMN1; SMN2HPGDTSHRBPTF | |
| Nebracetam SCHEMBL195354 | 0.84 | HPGD (0.60) | HTTSMN1; SMN2HPGDTSHRDPP4 | |
| SCHEMBL9456927 | 0.82 | DPP4 (0.44) | HTTSMN1; SMN2HPGDTSHRBPTF | |
| SCHEMBL9462245 | 0.81 | ALDH1A1 (0.51) | SMN1; SMN2 | |
| SCHEMBL9456724 | 0.80 | TDP1 (0.54) | SMN1; SMN2HPGDTSHRTDP1 | |
| Nebracetam SCHEMBL678462 | 0.79 | HPGD (0.51) | HTTSMN1; SMN2HPGDTSHRDPP4 | |
| Nebracetam SCHEMBL1030649 | 0.79 | HPGD (0.51) | HTTSMN1; SMN2HPGDTSHRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217967-A | Tricyclic antidepressant co-administered with a N-benzylpyrrolidin-2-one | BOEHRINGER INGELHEIM GMBH (DE) | 1993-06-08 | — | — | US | disclosed |
| US-5149808-A | Nootropics, antihypoxic agents | BOEHRINGER INGELHEIM KG (DE) | 1992-09-22 | — | — | US | disclosed |
| EP-0266563-B1 | USE OF 1-BENZYL-AMINO-ALKYL-PYRROLIDINONES AS ANTIDEPRESSANTS | BOEHRINGER INGELHEIM KG (DE) | 1992-01-29 | — | — | EP | disclosed |
| EP-0280290-B1 | AGENT HAVING AN ANTIDEPRESSIVE ACTIVITY | BOEHRINGER INGELHEIM KG (DE) | 1992-01-08 | — | — | EP | disclosed |
| US-5073671-A | Nootropic and antihypoxic agents | BOEHRINGER INGELHEIM KG (DE) | 1991-12-17 | — | — | US | disclosed |
| US-4954516-A | Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants | BOEHRINGER INGELHEIM KG (DE) | 1990-09-04 | — | — | US | disclosed |
| US-4931435-A | TRICYCLIC ANTIDEPRESSANT WITH BENZYLPYRROLIDINONE; SIDE EFFECT REDUCTION | BOEHRINGER INGELHEIM KG (DE) | 1990-06-05 | — | — | US | disclosed |
| US-4912129-A | Administering to humans | BOEHRINGER INGELHEIM GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| US-4833140-A | ANTIHYPOXIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 1989-05-23 | — | — | US | disclosed |
| EP-0136658-B1 | -1-BENZYL-AMINOALKYL-PYRROLIDINONES AND THEIR ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | BOEHRINGER INGELHEIM KG (DE) | 1989-04-26 | — | — | EP | disclosed |
| US-4812453-A | Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants | BOEHRINGER INGELHEIM KG (DE) | 1989-03-14 | — | — | US | disclosed |
| EP-0280290-A2 | Agent having an antidepressive activity | BOEHRINGER INGELHEIM KG (DE) | 1988-08-31 | — | — | EP | disclosed |
| US-4767759-A | ANTIHYPOXICS | BOEHRINGER INGELHEIM KG (DE) | 1988-08-30 | — | — | US | disclosed |
| EP-0266563-A2 | Use of 1-benzyl-amino-alkyl-pyrrolidinones as antidepressants | BOEHRINGER INGELHEIM KG (DE) | 1988-05-11 | — | — | EP | disclosed |
| EP-0136658-A2 | -1-Benzyl-aminoalkyl-pyrrolidinones and their addition salts, process for their preparation and pharmaceutical compounds containing them | BOEHRINGER INGELHEIM KG (DE) | 1985-04-10 | — | — | EP | disclosed |