Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458382 | 1.00 | HTR1A (0.54) | HTR1AADRA1BDRD2 | |
| SCHEMBL8142986 | 1.00 | HTR1A (0.54) | HTR1AADRA1BDRD2 | |
| SCHEMBL8144144 | 1.00 | HTR1A (0.54) | HTR1AADRA1BDRD2 | |
| SCHEMBL9458377 | 1.00 | HTR1A (0.54) | HTR1AADRA1BDRD2 | |
| SCHEMBL9458306 | 0.93 | HTR1A (0.52) | HTR1AADRA1B | |
| SCHEMBL9458301 | 0.93 | HTR1A (0.52) | HTR1AADRA1B | |
| SCHEMBL9458298 | 0.93 | HTR1A (0.52) | HTR1AADRA1B | |
| SCHEMBL7851460 | 0.92 | HTR1A (0.51) | HTR1AADRA1B | |
| SCHEMBL9812520 | 0.89 | HTR1A (0.65) | HTR1AADRA1BDRD2 | |
| SCHEMBL9458004 | 0.89 | HTR1A (0.65) | HTR1AADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | claimed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | claimed |
| US-5244888-A | Hexahydroindenopyrroles and hexahydrobenzisoindoles | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| US-5049564-A | Hypotensive, 5-hydroxytryptamine | ABBOTT LABORATORIES (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |