Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458898 | 0.77 | — | — | |
| SCHEMBL9710719 | 0.77 | — | — | |
| SCHEMBL9459439 | 0.76 | CHRM2 (0.48) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL9442633 | 0.75 | CHRM2 (0.47) | CHRNA7 | |
| SCHEMBL9459255 | 0.74 | CHRNA7 (0.53) | CHRNA7 | |
| SCHEMBL9431318 | 0.73 | CHRNA7 (0.49) | CHRNA7 | |
| SCHEMBL9293824 | 0.72 | — | — | |
| SCHEMBL9459056 | 0.72 | CHRM2 (0.47) | — | |
| SCHEMBL7920405 | 0.71 | CHRNA7 (0.42) | CHRNA7 | |
| SCHEMBL6344857 | 0.71 | CHRNA7 (0.50) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | claimed |
| US-5260293-A | Simulate central muscarinic acetlycholine receptors | MERCK SHARP & DOHME LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | disclosed |