Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025977 | 0.92 | CHRNA7 (0.41) | — | |
| SCHEMBL2968389 | 0.92 | CHRNA7 (0.41) | — | |
| SCHEMBL9584936 | 0.83 | CHRM2 (0.41) | CHRM2CHRM1 | |
| SCHEMBL9458858 | 0.81 | CHRM2 (0.47) | CHRM2 | |
| Maleic Acid SCHEMBL9854125 | 0.81 | CHRNA7 (0.39) | — | |
| Maleic Acid SCHEMBL194353 | 0.81 | CHRNA7 (0.39) | — | |
| Cadaverine Tartrate SCHEMBL9710670 | 0.80 | CHRNA7 (0.35) | — | |
| Cadaverine Tartrate SCHEMBL9710674 | 0.80 | CHRNA7 (0.35) | — | |
| SCHEMBL9458552 | 0.78 | CHRM2 (0.42) | CHRM2CHRM1 | |
| SCHEMBL9458919 | 0.78 | CHRM2 (0.40) | CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | claimed |
| US-5260293-A | Simulate central muscarinic acetlycholine receptors | MERCK SHARP & DOHME LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| EP-0492903-A1 | Substituted pyrazines, pyrimidines and pyridazines for use in the treatment of glaucoma | MERCK SHARP & DOHME LTD. (GB) | 1992-07-01 | — | — | EP | disclosed |
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | disclosed |