Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL9710670 | 1.00 | CHRNA7 (0.35) | CHRNA7NPC1RAB9AALOX15KDM4E | |
| SCHEMBL5025977 | 0.87 | CHRNA7 (0.41) | CHRNA7 | |
| Maleic Acid SCHEMBL9854125 | 0.86 | CHRNA7 (0.39) | CHRNA7 | |
| Maleic Acid SCHEMBL194353 | 0.86 | CHRNA7 (0.39) | CHRNA7 | |
| Maleic Acid SCHEMBL29496245 | 0.86 | CHRNA7 (0.39) | CHRNA7 | |
| Cadaverine Tartrate SCHEMBL9171335 | 0.82 | KDM4E (0.33) | CHRNA7ALOX15KDM4EBLM | |
| Cadaverine Tartrate SCHEMBL9168257 | 0.82 | KDM4E (0.33) | CHRNA7ALOX15KDM4EBLM | |
| SCHEMBL9459002 | 0.80 | CHRM2 (0.40) | — | |
| SCHEMBL8961518 | 0.76 | CHRNA7 (0.41) | CHRNA7 | |
| Oxalic Acid SCHEMBL9459416 | 0.74 | CHRNA7 (0.39) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470668-A1 | A process for preparing enantiomers of compounds having muscarinic activity | MERCK SHARP & DOHME LTD. (GB) | 1992-02-12 | — | — | EP | disclosed |
| US-5073557-A | Cognition activators, stimulants of central muscarinic acetylc holine receptors | MERCK SHARP & DOHME LIMITED (GB) | 1991-12-17 | — | — | US | disclosed |
| EP-0416754-A2 | A novel substituted pyrazine, formulations thereof and use in medicine | MERCK SHARP & DOHME LTD. (GB) | 1991-03-13 | — | — | EP | disclosed |