Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9459054 | 0.82 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EGLAMAPT | |
| SCHEMBL6994905 | 0.73 | KDM4E (0.39) | ALDH1A1HPGDKDM4EMAPK1L3MBTL1 | |
| SCHEMBL15407033 | 0.71 | DAO (0.69) | ALDH1A1HPGDKDM4EMAPK1L3MBTL1 | |
| SCHEMBL13550064 | 0.71 | KDM4E (0.66) | ALDH1A1HPGDKDM4EMAPK1L3MBTL1 | |
| SCHEMBL7218427 | 0.71 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4EMAPK1L3MBTL1 | |
| SCHEMBL13550058 | 0.70 | KDM4E (0.52) | ALDH1A1HPGDKDM4EMAPK1L3MBTL1 | |
| SCHEMBL28870911 | 0.70 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4EMAPK1L3MBTL1 | |
| SCHEMBL12883525 | 0.70 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4EMAPK1L3MBTL1 | |
| SCHEMBL6995377 | 0.69 | MAPT (0.41) | ALDH1A1HPGDKDM4EMAPK1L3MBTL1 | |
| SCHEMBL13550073 | 0.69 | KDM4E (0.48) | ALDH1A1HPGDKDM4EMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5216020-A | Antiglaucoma and occular hyptotensive agents | MERCK & CO., INC. (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0480692-A2 | Substituted 4,5-dihydrothieno[2,3-b]thiophene-2-sulfonamides | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |