Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458876 | 0.81 | HTR3A (0.40) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9459266 | 0.81 | CHRM2 (0.37) | CHRM2HTR3A | |
| SCHEMBL9459319 | 0.78 | HTR3A (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9459183 | 0.78 | CHRM2 (0.37) | CHRM2HTR3A | |
| SCHEMBL9459086 | 0.77 | CHRM2 (0.40) | CHRM2 | |
| SCHEMBL9459215 | 0.75 | HTR3A (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9459055 | 0.75 | HTR3A (0.34) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9459096 | 0.75 | CTPS1 (0.32) | CHRM2CHRM1 | |
| SCHEMBL9458887 | 0.71 | HTR3A (0.44) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9458830 | 0.71 | CHRM2 (0.34) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260293-A | Simulate central muscarinic acetlycholine receptors | MERCK SHARP & DOHME LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | disclosed |