Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.46 |
| ▸ | APP | P05067 | 3/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945867 | 0.83 | BACE1 (0.43) | BACE1APPBACE2CTSD | |
| SCHEMBL946334 | 0.81 | BACE1 (0.52) | BACE1BACE2KCNH2 | |
| SCHEMBL945531 | 0.81 | BACE1 (0.51) | BACE1APPBACE2KCNH2 | |
| SCHEMBL943868 | 0.80 | BACE1 (0.64) | BACE1BACE2KCNH2 | |
| SCHEMBL945166 | 0.79 | BACE1 (0.45) | BACE1APPBACE2KCNH2 | |
| SCHEMBL944883 | 0.78 | BACE1 (0.54) | BACE1APPBACE2KCNH2 | |
| SCHEMBL932295 | 0.63 | BACE1 (1.00) | BACE1BACE2KCNH2 | |
| SCHEMBL948729 | 0.63 | BACE1 (0.42) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL932452 | 0.62 | BACE1 (1.00) | BACE1BACE2KCNH2 | |
| SCHEMBL9948389 | 0.62 | BACE1 (1.00) | BACE1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |