Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 13/20 | 0.43 |
| ▸ | CTSD | P07339 | 12/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945976 | 0.83 | BACE1 (0.46) | BACE1BACE2CTSDAPP | |
| SCHEMBL948729 | 0.80 | BACE1 (0.42) | BACE1BACE2CTSD | |
| SCHEMBL4527011 | 0.63 | RPS6KA3 (0.45) | BACE1APPPGR | |
| SCHEMBL945531 | 0.62 | BACE1 (0.51) | BACE1BACE2APP | |
| SCHEMBL945166 | 0.59 | BACE1 (0.45) | BACE1BACE2APP | |
| SCHEMBL15344206 | 0.59 | RAB9A (0.51) | — | |
| SCHEMBL21324356 | 0.58 | CHRM1 (0.48) | — | |
| SCHEMBL3048969 | 0.57 | TAAR1 (0.45) | PGR | |
| SCHEMBL2171711 | 0.56 | CYP3A4 (0.46) | BACE1APPPGR | |
| SCHEMBL10091244 | 0.56 | PGR (0.44) | BACE1APPPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |