Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | TTR | P02766 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10414212 | 0.77 | ALDH1A1 (0.46) | ALDH1A1CYP3A4SMN1; SMN2HPGDLMNA | |
| SCHEMBL2705285 | 0.77 | TSHR (0.45) | ALDH1A1HSD17B10TSHRCYP3A4HPGD | |
| SCHEMBL13879111 | 0.73 | TSHR (0.42) | ALDH1A1TSHRCYP3A4SMN1; SMN2HPGD | |
| SCHEMBL4674100 | 0.73 | ALDH1A1 (0.50) | ALDH1A1CYP3A4SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL21883260 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HSD17B10TSHRCYP3A4HPGD | |
| SCHEMBL11862552 | 0.72 | HSD17B10 (0.46) | ALDH1A1HSD17B10TSHRTTRCYP3A4 | |
| SCHEMBL9807709 | 0.72 | HSD17B10 (0.55) | ALDH1A1HSD17B10TSHRTTRCYP3A4 | |
| SCHEMBL5028743 | 0.72 | HSD17B10 (0.55) | ALDH1A1HSD17B10TSHRTTRCYP3A4 | |
| SCHEMBL5635782 | 0.70 | ALDH1A1 (0.40) | ALDH1A1HSD17B10SMN1; SMN2ALOX15HPGD | |
| SCHEMBL4897669 | 0.69 | TTR (0.52) | ALDH1A1HSD17B10TSHRTTRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372409-B1 | Acylaminoalkylpyridineamides as inhibitors of tumor metastasis | SEARLE & CO (US) | 1993-10-27 | — | — | EP | disclosed |
| EP-0372410-B1 | Use of heterocyclic amides to inhibit tumor metastasis | SEARLE & CO (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5244899-A | Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders | G. D. SEARLE AND CO. (US) | 1993-09-14 | — | — | US | disclosed |
| US-5229421-A | Antiallergens, antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5225444-A | Antiinflammatory agents or antiallergens | G. D. SEARLE & CO. (US) | 1993-07-06 | — | — | US | disclosed |
| US-5208262-A | Administering 4-hydroxythiophenol derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | disclosed |
| US-5198435-A | Antiinflammatory, antiallergen | G. D. SEARLE & CO. (US) | 1993-03-30 | — | — | US | disclosed |
| EP-0339688-B1 | HYDROXYPHENYLTHIOALKYLKETONES | G.D. Searle & Co. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5157053-A | Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders | G. D. SEARLE & CO. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0190683-B1 | NOVEL AMINOALKYLPYRDINEAMIDES | G.D. Searle & Co. (US) | 1992-09-16 | — | — | EP | disclosed |
| EP-0218782-B1 | LIPOXYGENASE-INHIBITING COMPOSITION AND HYDROXYPHENYLTHIOALKYLCARBONYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-16 | — | — | EP | disclosed |
| EP-0339688-A1 | Hydroxyphenylthioalkylketones | G.D. Searle & Co. (US) | 1989-11-02 | — | — | EP | disclosed |
| EP-0338595-A1 | Hydroxyphenylthioalkylketoalcohols | G.D. Searle & Co. (US) | 1989-10-25 | — | — | EP | disclosed |
| US-4857558-A | ANTIINFLAMMATORY AGENTS AND-OR ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1989-08-15 | — | — | US | disclosed |
| US-4663333-A | Acylaminoalkylpyridines ad use in treatment of inflammation and allergy reactions | G. D. SEARLE & CO. (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0218782-A1 | Lipoxygenase-inhibiting composition and hydroxyphenylthioalkylcarbonyl compounds | G.D. Searle & Co. (US) | 1987-04-22 | — | — | EP | disclosed |
| EP-0190682-A2 | Novel disubstituted 4-hydroxyphenylthio anilides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |
| EP-0190684-A2 | Bicycloalkyl, tricycloalkyl, azabicycloalkyl and azatricycloalkyl amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |
| EP-0190683-A2 | Novel aminoalkylpyrdineamides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |
| EP-0190685-A2 | Heterocyclic amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |