Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9464771 | 0.90 | TP53 (0.49) | POLBGLAHPGDCYP11B1CYP11B2 | |
| SCHEMBL9464177 | 0.84 | CYP11B1 (0.55) | POLBCYP11B1CYP11B2GAAHTR6 | |
| SCHEMBL5024162 | 0.81 | POLB (0.58) | POLBGLAHPGDCYP11B1CYP11B2 | |
| SCHEMBL288153 | 0.80 | NPC1 (0.62) | POLBGLAHPGDCYP11B1CYP11B2 | |
| SCHEMBL30264508 | 0.80 | POLB (0.57) | POLBGLAHPGDCYP11B1CYP11B2 | |
| SCHEMBL852214 | 0.80 | POLB (0.57) | POLBGLAHPGDCYP11B1CYP11B2 | |
| SCHEMBL4710261 | 0.78 | POLB (0.66) | POLBGLAHPGDCYP11B1CYP11B2 | |
| SCHEMBL5018919 | 0.78 | SMN1; SMN2 (0.55) | POLBGLAHPGDCYP11B1CYP11B2 | |
| SCHEMBL14057787 | 0.76 | HPGD (0.69) | POLBHPGDNPC1MEN1KMT2A | |
| SCHEMBL12682923 | 0.76 | HPGD (0.69) | POLBHPGDNPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258399-A | 5-lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-11-02 | — | — | US | disclosed |
| US-5236948-A | Lipoxygenase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |