Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9464330 | 0.83 | NOTUM (0.65) | NOTUMMAPTSMN1; SMN2GAAMEN1 | |
| SCHEMBL9669957 | 0.83 | TUBB4A (0.46) | NOTUMTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9464637 | 0.82 | NOTUM (0.65) | NOTUMMAPTNPSR1HSD17B10SMN1; SMN2 | |
| SCHEMBL9826202 | 0.81 | NOTUM (1.00) | NOTUMMAPTHTTKMT2AMAPK1 | |
| SCHEMBL9669398 | 0.81 | MAPT (0.46) | NOTUMLMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL28986741 | 0.80 | NOTUM (0.61) | NOTUM | |
| SCHEMBL1882075 | 0.80 | NOTUM (0.55) | NOTUMMAPTKMT2A | |
| SCHEMBL12191258 | 0.80 | NOTUM (0.67) | NOTUMLMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL1873413 | 0.79 | NOTUM (0.67) | NOTUMLMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL21639372 | 0.79 | NOTUM (0.67) | NOTUMLMNAHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5179111-A | IMIDAZOLE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-01-12 | — | — | US | claimed |
| EP-0323799-B1 | IMIDAZOLE DERIVATIVES II | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-11-11 | — | — | EP | claimed |
| US-5179111-A | IMIDAZOLE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-01-12 | — | — | US | disclosed |