Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946523 | 1.00 | MAPKAPK2 (0.42) | MAPKAPK2SIRT1ABCG2ABCB1KIF11 | |
| SCHEMBL949319 | 0.89 | BRD3 (0.40) | MAPKAPK2SIRT1ABCG2ABCB1KIF11 | |
| SCHEMBL949317 | 0.89 | BRD3 (0.40) | MAPKAPK2SIRT1ABCG2ABCB1KIF11 | |
| SCHEMBL947568 | 0.84 | TRPV1 (0.49) | MAPKAPK2SIRT1KIF11MAPTTP53 | |
| SCHEMBL949021 | 0.83 | KIF11 (0.47) | MAPKAPK2SIRT1ABCG2ABCB1KIF11 | |
| SCHEMBL945721 | 0.78 | MAPKAPK2 (0.56) | MAPKAPK2ABCG2MAPTTP53HTT | |
| SCHEMBL951334 | 0.74 | S1PR1 (0.60) | MAPKAPK2ABCG2ABCB1 | |
| SCHEMBL2566334 | 0.72 | S1PR1 (0.51) | MAPKAPK2SIRT1 | |
| SCHEMBL2566332 | 0.72 | S1PR1 (0.51) | MAPKAPK2SIRT1 | |
| SCHEMBL944763 | 0.72 | TRPV1 (0.50) | MAPKAPK2SIRT1KIF11MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |