Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 12/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12320539 | 0.84 | S1PR1 (0.59) | S1PR1SRD5A2MEN1KMT2ANPC1 | |
| SCHEMBL947071 | 0.83 | S1PR1 (0.44) | S1PR1MEN1KMT2AMAOB | |
| SCHEMBL946723 | 0.81 | S1PR1 (0.84) | S1PR1S1PR5 | |
| SCHEMBL945998 | 0.75 | S1PR1 (0.54) | S1PR1SRD5A2MEN1KMT2ANPC1 | |
| SCHEMBL12944511 | 0.74 | S1PR1 (0.79) | S1PR1S1PR5 | |
| SCHEMBL2207599 | 0.74 | S1PR1 (0.69) | S1PR1SRD5A2S1PR5 | |
| SCHEMBL12320536 | 0.74 | S1PR1 (0.69) | S1PR1SRD5A2S1PR5 | |
| SCHEMBL14321367 | 0.72 | S1PR1 (0.57) | S1PR1SRD5A2MEN1KMT2ANPC1 | |
| SCHEMBL2019616 | 0.72 | S1PR1 (0.57) | S1PR1SRD5A2MEN1KMT2ANPC1 | |
| SCHEMBL14327899 | 0.72 | S1PR1 (0.53) | S1PR1SRD5A2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |