Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.44 |
| ▸ | MIF | P14174 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946678 | 0.86 | S1PR1 (0.45) | S1PR1MIFF2 | |
| SCHEMBL948546 | 0.84 | S1PR1 (0.55) | S1PR1 | |
| SCHEMBL12320236 | 0.81 | S1PR1 (0.46) | S1PR1MIFGAAMAPK1ALDH1A1 | |
| SCHEMBL2017262 | 0.79 | S1PR1 (0.53) | S1PR1MIFGAAMAPK1ALDH1A1 | |
| SCHEMBL949211 | 0.70 | S1PR1 (0.41) | S1PR1MIFF2 | |
| SCHEMBL949210 | 0.70 | S1PR1 (0.41) | S1PR1MIFF2 | |
| SCHEMBL2446502 | 0.70 | S1PR1 (0.46) | S1PR1MIF | |
| SCHEMBL2446506 | 0.70 | S1PR1 (0.46) | S1PR1MIF | |
| SCHEMBL949133 | 0.68 | S1PR1 (0.41) | S1PR1 | |
| SCHEMBL4478554 | 0.67 | ALDH1A1 (0.57) | GAAALDH1A1ALOX15F2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |