Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954320 | 1.00 | S1PR1 (0.56) | S1PR1S1PR5S1PR4CYP2C9S1PR3 | |
| SCHEMBL947458 | 0.87 | S1PR1 (0.53) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL947456 | 0.87 | S1PR1 (0.53) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL948731 | 0.85 | S1PR1 (0.76) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL952344 | 0.81 | S1PR1 (0.77) | S1PR1S1PR5S1PR4CYP2C9 | |
| SCHEMBL947955 | 0.81 | S1PR1 (0.77) | S1PR1S1PR5S1PR4CYP2C9 | |
| SCHEMBL950655 | 0.79 | S1PR1 (0.78) | S1PR1S1PR5S1PR4CYP2C9 | |
| SCHEMBL946606 | 0.79 | S1PR1 (0.78) | S1PR1S1PR5S1PR4CYP2C9 | |
| SCHEMBL946608 | 0.79 | S1PR1 (0.78) | S1PR1S1PR5S1PR4CYP2C9 | |
| SCHEMBL946154 | 0.79 | S1PR1 (0.53) | S1PR1S1PR5S1PR4CYP2C9S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005290-A1 | DISUBSTITUTED OXADIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | claimed |
| WO-2011005290-A1 | DISUBSTITUTED OXADIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2011005290-A1 | DISUBSTITUTED OXADIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |