Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 5/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15586578 | 0.88 | TYR (0.52) | ALOX5CNR1CNR2ESR1ESR2 | |
| SCHEMBL11587871 | 0.85 | TYR (0.54) | ALOX5ESR1LMNAMAPTHIF1A | |
| SCHEMBL2052536 | 0.83 | ESR1 (0.53) | ESR1ESR2PRKCIERN1BACE1 | |
| SCHEMBL14220741 | 0.80 | IDO1 (0.34) | ALOX5HMGCRCNR1CNR2PRKCI | |
| SCHEMBL26586630 | 0.79 | ERN1 (0.39) | ALOX5ERN1BACE1LMNAMAPT | |
| SCHEMBL30014025 | 0.78 | ESR1 (0.55) | ALOX5HMGCRCNR1CNR2ESR1 | |
| SCHEMBL70464 | 0.78 | ESR1 (0.55) | ALOX5HMGCRCNR1CNR2ESR1 | |
| SCHEMBL5127450 | 0.78 | ALOX5 (0.68) | ALOX5HMGCRCNR1CNR2ESR1 | |
| SCHEMBL30250904 | 0.78 | ALOX5 (0.68) | ALOX5HMGCRCNR1CNR2ESR1 | |
| SCHEMBL26123823 | 0.78 | HIF1A (0.54) | ESR1ESR2ERN1PTPN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260294-A | Treatment of diseases caused by oxidative metabolism of arachidonic acid; antiinflammatory, antiallergins, antiarthriric | HOFFMAN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |
| US-5015661-A | Lipoxygenase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-05-14 | — | — | US | disclosed |