Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13606320 | 0.83 | MAPT (0.55) | MAPTPOLBTP53LMNATHRB | |
| SCHEMBL1670547 | 0.82 | EGFR (0.37) | MAPTPOLBTP53EGFRITK | |
| SCHEMBL13185172 | 0.81 | POLB (0.45) | MAPTPOLBTP53EGFRITK | |
| SCHEMBL13165272 | 0.81 | ALDH1A1 (0.45) | MAPTPOLBTP53EGFRITK | |
| SCHEMBL20927033 | 0.80 | MAPT (0.42) | MAPTPOLBTP53EGFRITK | |
| SCHEMBL1670973 | 0.80 | NOTUM (0.65) | MAPTPOLBTP53NOTUMLMNA | |
| SCHEMBL1908591 | 0.79 | KMT2A (0.46) | MAPTPOLBTP53EGFRITK | |
| SCHEMBL18568320 | 0.75 | CA12 (0.43) | MAPTPOLBTP53EGFRITK | |
| SCHEMBL2616853 | 0.73 | CA12 (0.44) | MAPTNOTUMCA12CA1CA2 | |
| SCHEMBL4139993 | 0.72 | CA12 (0.63) | MAPTNOTUMCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260294-A | Treatment of diseases caused by oxidative metabolism of arachidonic acid; antiinflammatory, antiallergins, antiarthriric | HOFFMAN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |
| US-5132310-A | Benzochroman compounds, lipoxygenase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1992-07-21 | — | — | US | disclosed |
| US-5015661-A | Lipoxygenase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-05-14 | — | — | US | disclosed |