Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | GRN | P28799 | 3/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017 | 0.90 | GRN (0.43) | GRNSORT1HCAR2HCAR3MAPT | |
| SCHEMBL27748841 | 0.85 | KDM5A (0.36) | KDM5AKDM5BKDM4CHCAR2HCAR3 | |
| SCHEMBL2934234 | 0.83 | KDM4E (0.47) | KDM5AKDM5BKDM4CGRNSORT1 | |
| SCHEMBL3572670 | 0.82 | GRN (0.45) | KDM5AKDM5BKDM4CGRNSORT1 | |
| SCHEMBL9468529 | 0.81 | SMN1; SMN2 (0.43) | KDM5AKDM5BKDM4CMAPTMEN1 | |
| SCHEMBL22151654 | 0.81 | GRN (0.40) | GRNSORT1HCAR3MAPTALDH1A1 | |
| SCHEMBL17288712 | 0.79 | KDM4E (0.46) | KDM5AKDM5BKDM4CGRNSORT1 | |
| SCHEMBL20503261 | 0.78 | KDM4E (0.45) | GRNSORT1HCAR2HCAR3KDM4E | |
| SCHEMBL25831179 | 0.77 | GRN (0.67) | GRNSORT1HCAR3MAPTKDM4E | |
| SCHEMBL2215308 | 0.77 | GRN (0.41) | GRNSORT1HCAR3MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252593-A | Hypotensive agents, cognition activators | GLAXO GROUP LIMITED (GB) | 1993-10-12 | — | — | US | disclosed |
| EP-0514217-A1 | Antihypertensive benzofuran derivatives carrying 4-pyrazolylmethyl substituents | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |