Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL948131 | 0.82 | JAK2 (0.46) | JAK2NTRK1 | |
| SCHEMBL15906074 | 0.78 | JAK2 (0.55) | JAK2NTRK1MAPK14 | |
| SCHEMBL4301490 | 0.76 | JAK2 (0.56) | JAK2NTRK1MAPK14CCNKCDK12 | |
| SCHEMBL18812935 | 0.76 | JAK2 (0.56) | JAK2NTRK1MAPK14CCNKCDK12 | |
| SCHEMBL4106214 | 0.75 | JAK2 (0.53) | JAK2NTRK1MAPK14CCNKCDK12 | |
| SCHEMBL949127 | 0.73 | NTRK1 (0.41) | JAK2NTRK1 | |
| SCHEMBL945616 | 0.69 | NTRK1 (1.00) | JAK2NTRK1 | |
| SCHEMBL19547403 | 0.66 | JAK2 (0.83) | JAK2NTRK1 | |
| SCHEMBL4306726 | 0.66 | MAPK14 (0.45) | JAK2NTRK1MAPK14CCNKCDK12 | |
| SCHEMBL30009510 | 0.66 | NTRK1 (1.00) | JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |