Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1037429 | 0.76 | P2RX7 (0.53) | P2RX7KDM4EHPGDHSD17B10LSS | |
| SCHEMBL458507 | 0.76 | P2RX7 (0.53) | P2RX7KDM4EHPGDHSD17B10LSS | |
| SCHEMBL11605633 | 0.76 | P2RX7 (0.58) | P2RX7KDM4EHPGDHSD17B10LSS | |
| SCHEMBL18039129 | 0.76 | P2RX7 (0.53) | P2RX7KDM4EHPGDHSD17B10LSS | |
| SCHEMBL17279823 | 0.74 | KDM4E (0.56) | P2RX7KDM4EHPGDHSD17B10LSS | |
| SCHEMBL10689031 | 0.72 | KDM4E (0.50) | P2RX7KDM4EHPGDHSD17B10LSS | |
| SCHEMBL1514733 | 0.71 | P2RX7 (0.68) | P2RX7KDM4EHPGDHSD17B10LSS | |
| SCHEMBL16797793 | 0.71 | P2RX7 (0.49) | P2RX7KDM4EHPGDHSD17B10LSS | |
| SCHEMBL6399282 | 0.71 | P2RX7 (0.68) | P2RX7KDM4EHPGDHSD17B10LSS | |
| SCHEMBL4503007 | 0.71 | P2RX7 (0.49) | P2RX7KDM4EHPGDHSD17B10LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5219857-A | Method of treating cognitive and related neural behavioral problems | AMERICAN CYANAMID COMPANY (US) | 1993-06-15 | — | — | US | claimed |
| US-5126340-A | Antidepressants | AMERICAN CYANAMID COMPANY (US) | 1992-06-30 | — | — | US | claimed |
| US-4562189-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1985-12-31 | — | — | US | claimed |
| US-5219857-A | Method of treating cognitive and related neural behavioral problems | AMERICAN CYANAMID COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| US-5219857-A | Method of treating cognitive and related neural behavioral problems | AMERICAN CYANAMID COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| US-5126340-A | Antidepressants | AMERICAN CYANAMID COMPANY (US) | 1992-06-30 | — | — | US | disclosed |
| US-5126340-A | Antidepressants | AMERICAN CYANAMID COMPANY (US) | 1992-06-30 | — | — | US | disclosed |
| US-4963553-A | TREATING COGNITIVE AND NEURAL BEHAVIORAL PROBLEMS IN MAMMALS | AMERICAN CYANAMID CO. (US) | 1990-10-16 | — | — | US | disclosed |
| US-4562189-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1985-12-31 | — | — | US | disclosed |