Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 5/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26193595 | 0.83 | KDM4E (0.85) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Rufloxacin SCHEMBL135502 | 0.83 | KDM4E (1.00) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Rufloxacin SCHEMBL8385662 | 0.82 | KDM4E (1.00) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Rufloxacin SCHEMBL51616 | 0.82 | KDM4E (1.00) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Rufloxacin SCHEMBL8126704 | 0.82 | KDM4E (1.00) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Rufloxacin SCHEMBL23282883 | 0.82 | KDM4E (0.98) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Rufloxacin SCHEMBL8390373 | 0.82 | KDM4E (1.00) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Rufloxacin SCHEMBL574492 | 0.82 | KDM4E (0.98) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Rufloxacin SCHEMBL12505914 | 0.82 | KDM4E (0.98) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Rufloxacin SCHEMBL1651162 | 0.82 | KDM4E (0.96) | KDM4EADRA2BMAPK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221741-A | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-06-22 | — | — | US | claimed |
| US-5221741-A | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-06-22 | — | — | US | disclosed |
| EP-0522277-A1 | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1993-01-13 | — | — | EP | disclosed |