Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045036 | 0.87 | KDM4E (1.00) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL12074980 | 0.86 | KDM4E (0.73) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL11636436 | 0.85 | KDM4E (0.71) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL5928677 | 0.84 | KDM4E (0.71) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL9796443 | 0.83 | ALDH1A1 (0.71) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL28280847 | 0.83 | ALDH1A1 (0.56) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL11865908 | 0.83 | KDM4E (0.55) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL3782005 | 0.82 | KDM4E (0.68) | KDM4EHSD17B10SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8977887 | 0.81 | MEN1 (0.58) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4311940 | 0.81 | KDM4E (0.66) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108558756-B | 2-aryl-2, 3-dihydro-4 (1H) -quinolinone semicarbazone compound and application thereof | 沈阳药科大学 | 2021-08-03 | — | — | CN | disclosed |
| US-5214059-A | Dermatitis, psoriasis | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-25 | — | — | US | disclosed |
| US-5166170-A | 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0406734-A2 | 2-(Aminoaryl)indoles and indolines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |