Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 8/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469678 | 1.00 | MME (0.45) | MMEBTKEPHX2SMN1; SMN2ALDH1A1 | |
| SCHEMBL9469674 | 1.00 | MME (0.45) | MMEBTKEPHX2SMN1; SMN2ALDH1A1 | |
| SCHEMBL9470264 | 0.90 | MME (0.47) | MMEALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL9470259 | 0.90 | MME (0.47) | MMEALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL9791484 | 0.88 | MME (0.53) | MMEEPHX2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL9791469 | 0.88 | MME (0.53) | MMEEPHX2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL9791478 | 0.88 | MME (0.53) | MMEEPHX2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7291524 | 0.79 | MME (0.51) | MMEALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL7302140 | 0.79 | MME (0.51) | MMEALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL9480679 | 0.78 | CTSK (0.41) | MMEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |