Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469850 | 1.00 | MME (0.72) | MMEALDH1A1GAATSHRCAPN1 | |
| SCHEMBL9470220 | 0.92 | MME (0.60) | MMEALDH1A1GAATSHRCAPN1 | |
| SCHEMBL9470216 | 0.92 | MME (0.60) | MMEALDH1A1GAATSHRCAPN1 | |
| SCHEMBL9469843 | 0.90 | MME (0.59) | MMEALDH1A1GAATSHRCAPN1 | |
| SCHEMBL9469837 | 0.90 | MME (0.59) | MMEALDH1A1GAATSHRCAPN1 | |
| SCHEMBL5924918 | 0.87 | MME (0.59) | MMEALDH1A1GAATSHRCAPN1 | |
| SCHEMBL9469547 | 0.85 | MME (0.77) | MMEALDH1A1GAATSHRCAPN1 | |
| SCHEMBL9469545 | 0.85 | MME (0.77) | MMEALDH1A1GAATSHRCAPN1 | |
| SCHEMBL6938274 | 0.85 | MME (0.57) | MMEALDH1A1GAATSHR | |
| SCHEMBL6938276 | 0.85 | MME (0.57) | MMEALDH1A1GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |