Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 15/20 | 0.49 |
| ▸ | CPB1 | P15086 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9470546 | 1.00 | MME (0.49) | MMECPB1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL9469892 | 0.84 | MME (0.52) | MMEALDH1A1GAATSHR | |
| SCHEMBL9469887 | 0.84 | MME (0.52) | MMEALDH1A1GAATSHR | |
| SCHEMBL9469473 | 0.79 | MME (0.58) | MME | |
| SCHEMBL9469469 | 0.79 | MME (0.58) | MME | |
| SCHEMBL5925056 | 0.77 | MME (0.49) | MMEALDH1A1 | |
| SCHEMBL9753833 | 0.77 | MME (0.49) | MMEALDH1A1 | |
| SCHEMBL5796118 | 0.76 | MME (0.48) | MMEALDH1A1 | |
| SCHEMBL9753159 | 0.75 | MME (0.42) | MMECPB1 | |
| SCHEMBL9753161 | 0.75 | MME (0.42) | MMECPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |