Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA2 | P00918 | 4/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469634 | 1.00 | ALDH1A1 (0.46) | ALDH1A1POLBL3MBTL1ALOX12TSHR | |
| SCHEMBL9470580 | 1.00 | ALDH1A1 (0.46) | ALDH1A1POLBL3MBTL1ALOX12TSHR | |
| SCHEMBL9469633 | 1.00 | ALDH1A1 (0.46) | ALDH1A1POLBL3MBTL1ALOX12TSHR | |
| SCHEMBL10401319 | 0.84 | ALDH1A1 (0.42) | ALDH1A1POLBL3MBTL1KDM4EKMT2A | |
| SCHEMBL9479809 | 0.82 | TSHR (0.41) | ALDH1A1POLBL3MBTL1TSHRHTT | |
| SCHEMBL9479814 | 0.82 | TSHR (0.41) | ALDH1A1POLBL3MBTL1TSHRHTT | |
| SCHEMBL9479804 | 0.82 | TSHR (0.41) | ALDH1A1POLBL3MBTL1TSHRHTT | |
| SCHEMBL21688377 | 0.81 | ALDH1A1 (0.45) | ALDH1A1ALOX12KDM4EKMT2AMEN1 | |
| SCHEMBL9469987 | 0.80 | ALDH1A1 (0.39) | ALDH1A1POLBL3MBTL1TSHRHTT | |
| SCHEMBL9623268 | 0.80 | MAPT (0.41) | ALDH1A1ALOX12KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| US-4960792-A | HYPOTENSIVE AGENTS | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| WO-1990009374-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1990-08-23 | — | — | WO | disclosed |