Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 0.86 |
| ▸ | PGR | P06401 | 5/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.86 |
| ▸ | CNR1 | P21554 | 1/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.61 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.61 |
| ▸ | AR | P10275 | 2/20 | 0.61 |
| ▸ | TNF | P01375 | 1/20 | 0.61 |
| ▸ | IL6 | P05231 | 1/20 | 0.61 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.61 |
| ▸ | GLUL | P15104 | 1/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.61 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9470879 | 1.00 | NR3C1 (0.86) | NR3C1PGRHIF1ALMNANR1I2 | |
| Rimexolone SCHEMBL29030109 | 0.92 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNANR1I2 | |
| Rimexolone SCHEMBL13693339 | 0.92 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNANR1I2 | |
| Rimexolone SCHEMBL3062722 | 0.92 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNANR1I2 | |
| Rimexolone SCHEMBL29030108 | 0.92 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNANR1I2 | |
| Rimexolone SCHEMBL445300 | 0.92 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNANR1I2 | |
| Rimexolone SCHEMBL1651214 | 0.92 | NR3C1 (1.00) | NR3C1PGRHIF1ALMNANR1I2 | |
| SCHEMBL9467031 | 0.91 | NR3C1 (0.84) | NR3C1PGRHIF1ALMNANR1I2 | |
| SCHEMBL9467039 | 0.91 | NR3C1 (0.84) | NR3C1PGRHIF1ALMNANR1I2 | |
| SCHEMBL9467046 | 0.91 | NR3C1 (0.84) | NR3C1PGRHIF1ALMNANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192755-A | Pregnane derivatives as immunomodulators | AKZO N.V. (NL) | 1993-03-09 | — | — | US | disclosed |
| EP-0231958-B1 | NOVEL PREGNANE DERIVATIVES, PROCESSES FOR THEIR PREPARATON AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AKZO N.V. (NL) | 1989-12-27 | — | — | EP | disclosed |
| EP-0231958-A1 | Novel pregnane derivatives, processes for their preparaton and pharmaceutical compositions containing same | AKZO N.V. (NL) | 1987-08-12 | — | — | EP | disclosed |