Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9472191 | 0.91 | KMT2A (0.55) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9471395 | 0.88 | CASR (0.59) | NPC1RAB9ATP53SMN1; SMN2KMT2A | |
| SCHEMBL9153540 | 0.85 | NPC1 (0.54) | NPC1RAB9ATP53SMN1; SMN2NFKB1 | |
| SCHEMBL9158424 | 0.84 | NPC1 (0.55) | NPC1RAB9ATP53SMN1; SMN2NFKB1 | |
| SCHEMBL9472100 | 0.83 | MEN1 (0.51) | NPC1RAB9ATP53SMN1; SMN2NFKB1 | |
| SCHEMBL9298232 | 0.83 | NPC1 (0.54) | NPC1RAB9ATP53SMN1; SMN2NFKB1 | |
| SCHEMBL9298227 | 0.83 | NPC1 (0.54) | NPC1RAB9ATP53SMN1; SMN2NFKB1 | |
| SCHEMBL9471740 | 0.79 | KMT2A (0.59) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9138009 | 0.79 | NPC1 (0.54) | NPC1RAB9ATP53SMN1; SMN2NFKB1 | |
| SCHEMBL9131910 | 0.79 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223529-A | Nervous system and gastrointestinal disorders | RHONE-POULENC SANTE (FR) | 1993-06-29 | — | — | US | disclosed |