⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029276 | 0.84 | — | — | |
| SCHEMBL6434568 | 0.83 | — | — | |
| SCHEMBL28243050 | 0.82 | — | — | |
| SCHEMBL6135421 | 0.80 | NAAA (0.32) | — | |
| SCHEMBL30102633 | 0.80 | NAAA (0.32) | — | |
| SCHEMBL30102635 | 0.80 | NAAA (0.32) | — | |
| SCHEMBL3126211 | 0.80 | — | — | |
| SCHEMBL9558521 | 0.79 | — | — | |
| SCHEMBL6946251 | 0.79 | — | — | |
| SCHEMBL10698739 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303570-A1 | KINASE INHIBITORS AND USES THEREOF | ABM THERAPEUTICS CORP (US) | 2023-09-28 | — | — | US | disclosed |
| US-20230303570-A1 | KINASE INHIBITORS AND USES THEREOF | ABM THERAPEUTICS CORP (US) | 2023-09-28 | — | — | US | disclosed |
| CN-107074828-B | Compounds and compositions as RAF kinase inhibitors | 诺华股份有限公司 | 2020-05-19 | — | — | CN | disclosed |
| EP-3191478-B1 | COMPOUNDS AND COMPOSITIONS AS RAF KINASE INHIBITORS | NOVARTIS AG (CH) | 2019-05-08 | — | — | EP | disclosed |
| US-10167279-B2 | Compounds and compositions as RAF kinase inhibitors | NOVARTIS AG (CH) | 2019-01-01 | — | — | US | disclosed |
| US-20180170917-A1 | COMPOUNDS AND COMPOSITIONS AS RAF KINASE INHIBITORS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2018-06-21 | — | — | US | disclosed |
| EP-3191478-A1 | COMPOUNDS AND COMPOSITIONS AS RAF KINASE INHIBITORS | Novartis AG (CH) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016038582-A1 | COMPOUNDS AND COMPOSITIONS AS RAF KINASE INHIBITORS | NOVARTIS AG (CH) | 2016-03-17 | — | — | WO | disclosed |
| US-5210271-A | INTERMEDIATES FOR THE PRODUCTION OF DIETHANOLAMINE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0474411-A1 | Production of diethanolamine derivatives and their intermediates | Takeda Chemical Industries, Ltd. (JP) | 1992-03-11 | — | — | EP | disclosed |
| US-4423076-A | ANTICARCINOGENIC AGENTS | NATIONAL FOUNDATION FOR CANCER RESEARCH, INC. (US) | 1983-12-27 | — | — | US | disclosed |