Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.75 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.75 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8032158 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Fumaric Acid SCHEMBL28369738 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Maleic Acid SCHEMBL28825253 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Fumaric Acid SCHEMBL289218 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Maleic Acid SCHEMBL289217 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Fumaric Acid SCHEMBL34467294 | 0.96 | TSHR (0.69) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Maleic Acid SCHEMBL19900430 | 0.96 | TSHR (0.69) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Maleic Acid SCHEMBL28240848 | 0.93 | TSHR (0.64) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Maleic Acid SCHEMBL8865128 | 0.92 | TSHR (0.75) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Fumaric Acid SCHEMBL15689651 | 0.92 | TSHR (0.75) | TSHRTP53EGLN1EGLN3FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103610674-B | Solid preparation containing micronized prasugrel | HAINAN LINGKANG PHARMACEUTICAL | 2015-01-07 | — | — | CN | claimed |
| CN-103610674-A | Solid preparation containing micronized prasugrel | HAINAN LINGKANG PHARMACEUTICAL | 2014-03-05 | — | — | CN | claimed |
| CN-115851563-B | Engineering bacterium for electrosynthesis of 3-hydroxybutyric acid by fixing carbon dioxide and construction method | 深圳中科翎碳生物科技有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-115851563-A | Engineering bacterium for electrosynthesis of 3-hydroxybutyric acid by fixing carbon dioxide and construction method | 深圳中科翎碳生物科技有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-114561416-B | Fixation of CO using electrical energy2Engineering bacteria for synthesizing isopropanol and construction method | 深圳中科翎碳生物科技有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114561416-A | Fixation of CO using electrical energy2Engineering bacteria for synthesizing isopropanol and construction method | 深圳中科翎碳生物科技有限公司 | 2022-05-31 | — | — | CN | disclosed |
| US-20210002332-A1 | SYSTEMS AND METHODS FOR FORMING BIOLOGICAL NANOWIRES AND APPLICATIONS THEREOF | YALE UNIVERSITY (US) | 2021-01-07 | — | — | US | disclosed |
| CN-108368075-A | Modified cytotoxins and therapeutic uses thereof | 加利福尼亚大学董事会 | 2018-08-03 | — | — | CN | disclosed |
| CN-103610674-B | Solid preparation containing micronized prasugrel | HAINAN LINGKANG PHARMACEUTICAL | 2015-01-07 | — | — | CN | disclosed |
| CN-103610674-A | Solid preparation containing micronized prasugrel | HAINAN LINGKANG PHARMACEUTICAL | 2014-03-05 | — | — | CN | disclosed |
| CN-1060775-C | Fused tropane-derivatives as neurotransmitter reuptake inhibitors | NEURORES AS (DK) | 2001-01-17 | — | — | CN | disclosed |
| CN-1201461-A | Fused tropane-derivatives as neurotransmitter reuptake inhibitors | NEURORESEARCH A S (DK) | 1998-12-09 | — | — | CN | disclosed |
| US-5227300-A | Identification, characterization and method of production of a novel microbial lipase | OLIN CORPORATION (US) | 1993-07-13 | — | — | US | disclosed |
| US-5069810-A | LAUNDRY, DISHWASHING | OLIN CORPORATION (US) | 1991-12-03 | — | — | US | disclosed |
| US-5063160-A | From strains of pseudomonas | OLIN CORPORATION (US) | 1991-11-05 | — | — | US | disclosed |
| US-5059341-A | Cleaning composition comprising microbial lipase SD2, sodium dodecylbenzene sulfonate and gelatin | OLIN CORPORATION (US) | 1991-10-22 | — | — | US | disclosed |
| US-4390631-A | INCUBATION WITH A WATER SOLUBLE IRON COMPOUND | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1983-06-28 | — | — | US | disclosed |