SCHEMBL9474694

SCHEMBL9474694

CN(C)C(=O)NCNC(=O)N(C)C

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.48
CHRNA4 P43681 2/20 0.48
CHRNB4 P30926 1/20 0.48
TSHR P16473 6/20 0.38
ALDH1A1 P00352 5/20 0.37
MAPK1 P28482 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM4 P08173 1/20 0.33
CHRM5 P08912 1/20 0.33
CHRM1 P11229 1/20 0.33
CHRM3 P20309 1/20 0.33
NFKB1 P19838 1/20 0.32
THPO P40225 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MAPT P10636 1/20 0.32
APEX1 P27695 1/20 0.32
PMP22 Q01453 1/20 0.32
USP2 O75604 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21472085 0.80 CHRNB2 (0.48) CHRNB2CHRNA4CHRNB4TSHRALDH1A1
SCHEMBL8172250 0.79
SCHEMBL967318 0.79
SCHEMBL4685262 0.79
SCHEMBL4685261 0.79
SCHEMBL23110170 0.78 CHRNB2 (0.52) CHRNB2CHRNA4CHRNB4TSHRALDH1A1
SCHEMBL19347966 0.78 CHRNB2 (0.52) CHRNB2CHRNA4CHRNB4ALDH1A1MAPK1
SCHEMBL13137633 0.77
SCHEMBL426466 0.77
SCHEMBL18632063 0.75 CHRNB2 (0.48) CHRNB2CHRNA4CHRNB4TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5220061-A Slowyly mixing n,n dialkyl-n-phenylurea and methylene bis/ alkyl carbamate/ with acid catalyst; heating ARCO CHEMICAL TECHNOLOGY, L.P. (US) 1993-06-15 US disclosed
US-5206412-A Reacting alkylphenylcarbamate with methylene bis(alkyl carbamate); acid catlayst ARCO CHEMICAL TECHNOLOGY, L.P. (US) 1993-04-27 US disclosed