Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123094 | 0.88 | ERN1 (0.55) | ERN1ALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL26443965 | 0.83 | ERN1 (0.56) | ERN1ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL4657747 | 0.83 | ALDH1A1 (0.45) | ERN1ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL1403472 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL30203403 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL8164091 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL30095400 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL16166374 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL19673980 | 0.82 | ERN1 (0.51) | ERN1ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL9068677 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329681-B2 | Inhibitors of IMPDH enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329681-B2 | Inhibitors of IMPDH enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-02-12 | — | — | US | disclosed |
| US-5254578-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0482931-A1 | Benzopyran derivatives having anti-hypertensive and vasodilatory activity, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1992-04-29 | — | — | EP | disclosed |