SCHEMBL9475571

SCHEMBL9475571

CC1=C(C(=O)O)C(c2cccc(Cl)c2Cl)N(C(=O)O)C(=S)N1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 6/20 0.65
CACNA1D Q01668 6/20 0.65
CACNA1S Q13698 6/20 0.65
CACNA1C Q13936 6/20 0.65
TSHR P16473 3/20 0.45
ALDH1A1 P00352 4/20 0.42
CYP2C9 P11712 3/20 0.42
LMNA P02545 3/20 0.42
KDM4E B2RXH2 2/20 0.42
MEN1 O00255 2/20 0.42
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2C19 P33261 2/20 0.42
KMT2A Q03164 2/20 0.42
HIF1A Q16665 2/20 0.42
HSD17B10 Q99714 2/20 0.42
MAPT P10636 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
ABCB11 O95342 2/20 0.42
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9474962 0.91 CACNA1F (0.63) CACNA1FCACNA1DCACNA1SCACNA1CTSHR
SCHEMBL9476788 0.88 CACNA1F (0.67) CACNA1FCACNA1DCACNA1SCACNA1CTSHR
SCHEMBL9475527 0.87 CACNA1F (0.53) CACNA1FCACNA1DCACNA1SCACNA1CTSHR
SCHEMBL9475596 0.85 CACNA1C (0.68) CACNA1FCACNA1DCACNA1SCACNA1CTSHR
SCHEMBL9475842 0.83 CACNA1F (0.47) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL7266696 0.82 CACNA1F (0.56) CACNA1FCACNA1DCACNA1SCACNA1CTSHR
SCHEMBL9805713 0.79 CACNA1F (0.46) CACNA1FCACNA1DCACNA1SCACNA1CTSHR
SCHEMBL9805710 0.79 CACNA1F (0.46) CACNA1FCACNA1DCACNA1SCACNA1CTSHR
SCHEMBL9475672 0.79 CACNA1F (0.44) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL9476049 0.79 CACNA1F (0.64) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5202330-A Hypotensive and cardiovascular agent, reduces blood pressure in mammals E. R. SQUIBB & SONS, INC. (US) 1993-04-13 US disclosed
EP-0204317-A2 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters E.R. Squibb & Sons, Inc. (US) 1986-12-10 EP disclosed