Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 13/20 | 0.68 |
| ▸ | CACNA1F | O60840 | 12/20 | 0.68 |
| ▸ | CACNA1D | Q01668 | 12/20 | 0.68 |
| ▸ | CACNA1S | Q13698 | 12/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475008 | 0.91 | CACNA1F (0.66) | CACNA1CCACNA1FCACNA1DCACNA1SKMT2A | |
| SCHEMBL9477065 | 0.89 | CACNA1F (0.67) | CACNA1CCACNA1FCACNA1DCACNA1SKMT2A | |
| SCHEMBL9475098 | 0.89 | CACNA1C (0.57) | CACNA1CCACNA1FCACNA1DCACNA1SKMT2A | |
| SCHEMBL9475571 | 0.85 | CACNA1F (0.65) | CACNA1CCACNA1FCACNA1DCACNA1SKMT2A | |
| SCHEMBL10914501 | 0.81 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SALDH1A1 | |
| SCHEMBL9474962 | 0.81 | CACNA1F (0.63) | CACNA1CCACNA1FCACNA1DCACNA1SSMN1; SMN2 | |
| SCHEMBL9475708 | 0.81 | CACNA1C (0.56) | CACNA1CCACNA1FCACNA1DCACNA1SKMT2A | |
| SCHEMBL9157120 | 0.80 | CACNA1C (0.56) | CACNA1CCACNA1FCACNA1DCACNA1SKMT2A | |
| SCHEMBL9475454 | 0.79 | CACNA1D (0.53) | CACNA1CCACNA1FCACNA1DCACNA1SKMT2A | |
| SCHEMBL9475842 | 0.78 | CACNA1F (0.47) | CACNA1CCACNA1FCACNA1DCACNA1SKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |