SCHEMBL9475708

SCHEMBL9475708

CC1=C(C(=O)O)C(c2cccc([N+](=O)[O-])c2Cl)N(C(=O)C(C)C)C(=O)N1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 8/20 0.56
CACNA1D Q01668 8/20 0.56
CACNA1F O60840 7/20 0.56
CACNA1S Q13698 7/20 0.56
SMN1; SMN2 Q16637 2/20 0.41
ALDH1A1 P00352 3/20 0.40
KMT2A Q03164 3/20 0.40
MAPT P10636 2/20 0.40
ABCC4 O15439 2/20 0.40
ABCB11 O95342 2/20 0.40
LMNA P02545 2/20 0.40
CYP1A2 P05177 2/20 0.40
ADORA3 P0DMS8 2/20 0.40
ADORA2A P29274 2/20 0.40
ADORA1 P30542 2/20 0.40
OPRM1 P35372 2/20 0.40
SCN1A P35498 2/20 0.40
HTR2B P41595 2/20 0.40
KCNH2 Q12809 2/20 0.40
SCN5A Q14524 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9477065 0.90 CACNA1F (0.67) CACNA1CCACNA1DCACNA1FCACNA1SSMN1; SMN2
SCHEMBL9475098 0.89 CACNA1C (0.57) CACNA1CCACNA1DCACNA1FCACNA1SSMN1; SMN2
SCHEMBL7266642 0.87 CACNA1D (0.51) CACNA1CCACNA1DCACNA1FCACNA1SSMN1; SMN2
SCHEMBL9475596 0.81 CACNA1C (0.68) CACNA1CCACNA1DCACNA1FCACNA1SSMN1; SMN2
SCHEMBL9475454 0.80 CACNA1D (0.53) CACNA1CCACNA1DCACNA1FCACNA1SSMN1; SMN2
SCHEMBL9157120 0.78 CACNA1C (0.56) CACNA1CCACNA1DCACNA1FCACNA1SSMN1; SMN2
SCHEMBL9476298 0.74 CACNA1D (0.48) CACNA1CCACNA1DCACNA1FCACNA1SSMN1; SMN2
SCHEMBL10642791 0.73 CACNA1F (0.43) CACNA1CCACNA1DCACNA1FCACNA1SSMN1; SMN2
SCHEMBL9475527 0.73 CACNA1F (0.53) CACNA1CCACNA1DCACNA1FCACNA1SALDH1A1
SCHEMBL10914501 0.71 CACNA1C (1.00) CACNA1CCACNA1DCACNA1FCACNA1SALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5202330-A Hypotensive and cardiovascular agent, reduces blood pressure in mammals E. R. SQUIBB & SONS, INC. (US) 1993-04-13 US disclosed
EP-0204317-A2 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters E.R. Squibb & Sons, Inc. (US) 1986-12-10 EP disclosed