Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 17/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946557 | 0.86 | S1PR1 (0.48) | S1PR1S1PR3S1PR4S1PR5HDAC6 | |
| SCHEMBL3428752 | 0.84 | S1PR1 (0.47) | S1PR1S1PR4S1PR5HDAC6HDAC1 | |
| SCHEMBL945267 | 0.83 | S1PR1 (0.40) | S1PR1HDAC6HDAC1HDAC8 | |
| SCHEMBL3750093 | 0.82 | MAPT (0.43) | — | |
| SCHEMBL3426943 | 0.81 | S1PR1 (0.43) | S1PR1S1PR3S1PR5HDAC6HDAC1 | |
| SCHEMBL947598 | 0.80 | S1PR1 (0.58) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL3431635 | 0.80 | S1PR1 (0.43) | S1PR1S1PR4S1PR5HDAC6HDAC1 | |
| SCHEMBL3429275 | 0.80 | S1PR1 (0.43) | S1PR1S1PR3 | |
| SCHEMBL3752423 | 0.80 | S1PR1 (0.55) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL946044 | 0.80 | S1PR1 (0.42) | S1PR1S1PR3S1PR4S1PR5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005290-A1 | DISUBSTITUTED OXADIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |