Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 6/20 | 0.68 |
| ▸ | HTR3A | P46098 | 2/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.68 |
| ▸ | ACHE | P22303 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9477486 | 1.00 | HTR4 (0.68) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL9476025 | 1.00 | HTR4 (0.68) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL9477106 | 0.96 | HTR4 (0.63) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL9478667 | 0.96 | HTR4 (0.63) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL506124 | 0.87 | HTR4 (0.54) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL506123 | 0.87 | HTR4 (0.54) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL506125 | 0.87 | HTR4 (0.54) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL30089324 | 0.86 | HTR4 (0.69) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL9479101 | 0.85 | HTR4 (0.78) | HTR4HTR3AHTR1AADRA2CACHE | |
| SCHEMBL6584440 | 0.84 | HTR4 (0.67) | HTR4HTR3AHTR1AADRA2CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262418-A | Laxatives, gastrointestinal disorders | TANSSEN PHARMACEUTICA N.V. (BE) | 1993-11-16 | — | — | US | disclosed |
| US-5185335-A | Administer to mammals to stimulate gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-02-09 | — | — | US | disclosed |